AbstractObjectives To assess the effects of treatments for non metastatic invasive squamous cell carcinoma (SCC) of the skin using evidence from observational studies, given the paucity of evidence from randomised controlled trials.Review methods Observational studies of interventions for primary, non metastatic, invasive, SCC of the skin that reported recurrence during follow up, quality of life, initial response to treatment, adverse events, cosmetic appearance, or death from disease. Studies were excluded if data for primary cutaneous SCC was not separable from other data. Data were extracted independently by two reviewers.
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